Synthesis and turnover rates of four rat liver mitochondrial RNA species

Authors:
  • PCP. Cantatore
    P. Cantatore
  • ZFZ. Flagella
    Z. Flagella
  • FFF. Fracasso
    F. Fracasso
  • ALA.M.S. Lezza
    A.M.S. Lezza
  • MGM.N. Gadaleta
    M.N. Gadaleta
  • AMA. de Montalvo
    A. de Montalvo
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Abstract
The synthesis and turnover rates of the two 12 S and 16 S mt rRNAs and of the mt mRNAs for subunits I and III of cytochrome oxidase have been determined by measuring the kinetics of incorporation of [3H]uridine in the mtRNA of rat hepatocytes. All the RNA species examined have approximately the same turnover (t ~ 100 min) and therefore the rate of synthesis, which is about 10‐times higher for the rRNAs, seems to be the factor responsible for the different mt rRNA and mRNA steady‐state levels.

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