Cellular Reactivity to Altered Glomerular Basement Membrane in Glomerulonephritis
Authors:
- Howard M. FillitHFHoward M. Fillit
- Stanley E. ReadSRStanley E. Read
- Raymond L. ShermanRSRaymond L. Sherman
- John B. ZabriskieJZJohn B. Zabriskie
- Ivo van de RijnIRIvo van de Rijn
- 20 April 1978
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 298 (16) , 861-868
Abstract
Glomerular basement membrane may be altered during glomerulonephritis, exposing antigens that are recognized as foreign. Immunochemical studies suggest that removal of peripheral glycopeptides from the basement membrane with glycosidase mimics this pathogenetic event. To examine these hypotheses, we studied 24 patients with biopsy-proved glomerulonephritis by means of the lymphocyte-blast-transformation assay. Three preparations of normal glomerular basement membrane were used: two mimicked the native state for the peripheral glycopeptides, and one was altered by glycosidases.Keywords
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