Whole exome sequencing in relapsed or refractory childhood cancer: case series
Open Access
- 1 August 2024
- journal article
- research article
- Published by Walter de Gruyter GmbH in Asian Biomedicine
- Vol. 18 (4) , 186-191
Abstract
Background: The prognosis for relapsed or refractory childhood cancer is approximately 20%. Genetic alterations are one of the significant contributing factors to the prognosis of patients. Objective: To investigate the molecular profile of relapsed or refractory childhood cancers in Thai cases. Methods: The study design is a descriptive study of patients NCOR2 , COL6A3 , TP53 , and SMAD4 genes. These alterations were found to be associated with tumor aggressiveness. Conclusion: This study is the first one to demonstrate genetic alterations by using WES in relapsed or refractory childhood cancer in Thai cases.Keywords
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