Topical (Intra-Articular) Tranexamic Acid Reduces Blood Loss and Transfusion Rates Following Total Knee Replacement
- 6 November 2013
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Bone and Joint Surgery
- Vol. 95 (21) , 1961-1968
Abstract
There are two surgical approaches for distal soft-tissue procedures for the correction of hallux valgus—the dorsal first web-space approach, and the medial transarticular approach. The purpose of this study was to compare the outcomes achieved after use of either of these approaches combined with a distal chevron osteotomy in patients with moderate to severe hallux valgus. One hundred and twenty-two female patients (122 feet) who underwent a distal chevron osteotomy as part of a distal soft-tissue procedure for the treatment of symptomatic unilateral moderate to severe hallux valgus constituted the study cohort. The 122 feet were randomly divided into two groups: namely, a dorsal first web-space approach (group D; sixty feet) and a medial transarticular approach (group M; sixty-two feet). The clinical and radiographic results of the two groups were compared at a mean follow-up time of thirty-eight months. The American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot scale hallux metatarsophalangeal-interphalangeal scores improved from a mean and standard deviation of 55.5 ± 12.8 points preoperatively to 93.5 ± 6.3 points at the final follow-up in group D and from 54.9 ± 12.6 points preoperatively to 93.6 ± 6.2 points at the final follow-up in group M. The mean hallux valgus angle in groups D and M was reduced from 32.2° ± 6.3° and 33.1° ± 8.4° preoperatively to 10.5° ± 5.5° and 9.9° ± 5.5°, respectively, at the time of final follow-up. The mean first intermetatarsal angle in groups D and M was reduced from 15.0° ± 2.8° and 15.3° ± 2.7° preoperatively to 6.5° ± 2.2° and 6.3° ± 2.4°, respectively, at the final follow-up. The clinical and radiographic outcomes were not significantly different between the two groups. The final clinical and radiographic outcomes between the two approaches for distal soft-tissue procedures were comparable and equally successful. Accordingly, the results of this study suggest that the medial transarticular approach is an effective and reliable means of lateral soft-tissue release compared with the dorsal first web-space approach. Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.Keywords
This publication has 16 references indexed in Scilit:
- Postoperative blood loss reduction in computer-assisted surgery total knee replacement by low dose intra-articular tranexamic acid injection together with 2-hour clamp drain: a prospective triple-blinded randomized controlled trialOrthopedic Reviews, 2011
- Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplastyInternational Orthopaedics, 2011
- TRANSFUSION COMPLICATIONS: Bacterial culture reduces but does not eliminate the risk of septic transfusion reactions to single‐donor plateletsTransfusion, 2009
- Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study☆European Journal of Cardio-Thoracic Surgery, 2007
- Bacterial Detection of Platelets: Current Problems and Possible ResolutionsTransfusion Medicine Reviews, 2005
- How much blood is really lost in total knee arthroplasty?The Knee, 2000
- A Comparative Study of the Postoperative Allogeneic Blood-Sparing Effect of Tranexamic Acid Versus Acute Normovolemic Hemodilution After Total Knee ReplacementAnesthesia & Analgesia, 1999
- Tranexamic Acid Radically Decreases Blood Loss and Transfusions Associated with Total Knee ArthroplastyAnesthesia & Analgesia, 1997
- THE EFFECT OF TRANEXAMIC ACID ON LOCAL AND PLASMA FIBRINOLYSIS DURING TOTAL KNEE ARTHROPLASTYThrombosis Research, 1997
- Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplastyBritish Journal of Anaesthesia, 1995