Asymmetric Hydrogenation of Cyclic α,β-Unsaturated Ketones to Chiral Allylic Alcohols

Authors:
  • TOTakeshi Ohkuma
    Takeshi Ohkuma
  • HIHideyuki Ikehira
    Hideyuki Ikehira
  • TITakao Ikariya
    Takao Ikariya
  • RNRyoji Noyori
    Ryoji Noyori
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Abstract
The Ru(II)-BINAP-1,2-diphenylethylenediamine combined catalyst system effects asymmetric hydrogenation of certain cyclic enones in 2-propanol containing KOH with a substrate/catalyst molar ratio of 250 to 2500. The hydrogenation occurs selectively at the C=O function with excellent enantio- or diastereoselectivity.