Interaction at a distance between λrepressers disrupts gene activation
Authors:
- M. PtashneMPM. Ptashne
- 1 November 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 336 (6197) , 353-357
Abstract
The lambda repressor is an activator as well as a repressor of transcription. The activation function is blocked by interaction with another lambda repressor molecule bound upstream on the same DNA molecule. This example of negative control at a distance involves formation of a DNA loop.Keywords
This publication has 30 references indexed in Scilit:
- Turning ? Cro into a transcriptional activatorCell, 1988
- A yeast silencer contains sequences that can promote autonomous plasmid replication and transcriptional activationCell, 1987
- DNA supercoiling promotes formation of a bent repression loop in lac DNAJournal of Molecular Biology, 1987
- Specific destruction of the second lac operator decreases repression of the lac operon in Escherichia coli fivefoldJournal of Molecular Biology, 1987
- A new-specificity mutant of 434 repressor that defines an amino acid–base pair contactNature, 1987
- DNA loops induced by cooperative binding of λ repressorNature, 1986
- Homologous interactions of λ repressor and λ Cro with the λ operatorCell, 1986
- Gene regulation at the right operator (OR) of bacteriophage λJournal of Molecular Biology, 1980
- Regulatory functions of the λ repressor reside in the amino-terminal domainNature, 1979
- Maximizing gene expression on a plasmid using recombination in vitroCell, 1978