A Role for Intestinal Alkaline Phosphatase in the Maintenance of Local Gut Immunity
Authors:
- Kathryn T. ChenKCKathryn T. Chen
- Madhu S. MaloMMMadhu S. Malo
- Laura Kline Beasley-TopliffeLBLaura Kline Beasley-Topliffe
- Klaas PoelstraKPKlaas Poelstra
- Jose Luis MillanJMJose Luis Millan
- Golam MostafaGMGolam Mostafa
- Sayeda N. AlamSASayeda N. Alam
- Sundaram RamasamySRSundaram Ramasamy
- H. Shaw WarrenHWH. Shaw Warren
- Elizabeth L. HohmannEHElizabeth L. Hohmann
- Richard A. HodinRHRichard A. Hodin
- 16 September 2010
- journal article
- research article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 56 (4) , 1020-1027
Abstract
Intestinal alkaline phosphatase (IAP) is a gut mucosal defense factor known to dephosphorylate lipopolysaccharide (LPS); however, the role of IAP in the gut response to luminal bacteria remains poorly defined. We investigated immune responses of wild-type (WT) and IAP-knockout (IAP-KO) mice to LPS and Salmonella typhimurium challenges.Keywords
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