Dynamic HPLC of stereolabile iron(II) complexes on chiral stationary phases
Abstract
A series of chiral tris‐(1,10)‐phenanthroline iron(II) complexes have been resolved by HPLC on chiral stationary phases based on either cellulose tris‐(3,5‐dimethylphenylcarbamate) or teicoplanin. At sub ambient temperatures, baseline separation of the enantiomers was observed for five different iron(II) complexes featuring substituted phenanthroline ligands. Dynamic HPLC profiles were observed near or above room temperature, indicating on‐column Δ/Λ enantiomerization. Rate constants for the Δ/Λ interconversion in free solution and during chromatography were obtained by thermal racemization experiments and by computer simulation of the HPLC dynamic plots, respectively. Chirality, 2009.Keywords
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