SERUM LEVELS OF THE ACID-ETHANOL SOLUBLE COMPONENT OF NON-SUPPRESSIBLE INSULIN-LIKE ACTIVITY IN UNTREATED AND TREATED STREPTOZOTOCIN-DIABETIC RATS

Authors:
  • RFR. C. Franklin
    R. C. Franklin
  • GRG. C. Rennie
    G. C. Rennie
  • DCD. P. Cameron
    D. P. Cameron
Publisher website
Google Scholar
Abstract
Streptozotocin-diabetic rats suffered growth failure and had reduced serum levels of the acid–ethanol soluble component of non-suppressible insulin-like activity (NSILA-S) compared with normal rats. Chronic insulin substitution (6 weeks) resulted in a normalization of serum levels of NSILA-S; this was accompanied by a normal increase in weight. Insulin therapy for 3 days resulted in a partial recovery of serum levels of NSILA-S and a slight but significant accompanying gain in weight. Short-term administration of GH also resulted in a partial recovery of the serum level of NSILA-S, in spite of continued uncontrolled diabetes. These results demonstrate that, in the rat, insulin as well as GH contributes to the regulation of serum levels of NSILA-S.