Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer
- 13 September 2021
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 118 (38)
Abstract
Significance: There is clear and irrefutable evidence that the Notch developmental signaling pathway is an important driver in many cancers, specifically in breast cancer. However, because of the ubiquity of this pathway in normal tissues, therapeutics targeting Notch have been associated with significant deleterious side effects. Herein, we provide evidence that USP9x selectively drives Notch in breast cancer and that therapeutic USP9x inhibition prevents tumor progression without collateral damage to normal tissues.Keywords
Funding Information
- Canadian Cancer Society Research Institute (#705788)
- Canadian Cancer Society Research Institute (#705788)
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