Platelet-rich plasma plus bioactive glass in the treatment of intra-bony defects: a study in dogs

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Abstract
Objective: This study was designed to evaluate, histomorphometrically, the association of platelet-rich plasma (PRP) and bioactive glass (BG) in the treatment of periodontal intrabony defects. Material and Methods: Nine mongrel dogs were included in the study. Three-wall intrabony defects were surgically created at the mesial and distal aspect of first mandibularmolar and exposed to plaque accumulation for 1 month. The defects were randomly assigned to the groups: control, BG, PRP, PRP+BG. Dogs were sacrificed 90 days after the surgeries. The histometric parameters evaluated were: length of sulcular and junctional epithelium, connective tissue adaptation, new cementum, new bone, defect extension and area of new bone filling the defect. Results: A superior area of new bone was observed in PRP+BG and BG (13.80 +/- 2.32 mm(2) and 15.63 +/- 2.64 mm(2), respectively) when compared to the other groups (8.19 +/- 1.46 mm(2) and 8.81 +/- 1.47 mm(2) for control and PRP, respectively). No statistically significant differences were observed in the reamining parameters. Conclusions: Within the limits of this study, it may be concluded that PRP failed to provide statistically significant improvements in the histometric parameters.

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