Myoclonus in patients with COVID‐19: Findings of autoantibodies against brain structures in cerebrospinal fluid

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Abstract
Background and purpose: COVID‐19 is associated with multiple neurological manifestations. The clinical presentation, trajectory, and treatment response for three cases of myoclonus during COVID‐19 infection, with no previous neurological disease, are decsribed.Metods: Analysis of cerebrospinal fluid from the cases using indirect immunohistochemistry.Results: Antibodies against rodent brain tissue, and similarities in staining patterns were observed, indicating the presence of antineuronal immunoglobulin G autoantibodies targeting astrocytes in the hippocampus.Conclusion: Our results demontrate cerebrospinal fluid antineuronal antibodies indicating an an autoimmune involvment in the pathogenesis in COVID‐19 associated myoclonus.

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