Anti-Inflammatory Activity and Sub-Acute Toxicity of Artemetin1

Authors:
  • JSJayme A. A. Sertié
    Jayme A. A. Sertié
  • ABAulus C. Basile
    Aulus C. Basile
  • SPSylvio Panizza
    Sylvio Panizza
  • AMAmabile K. Matida
    Amabile K. Matida
  • RZRaymond Zelnik
    Raymond Zelnik
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Abstract
The 5-hydroxy-3,6,7,3′,4′-pentameth-oxyflavone (artemetin) from Cordia verbenacea DC (Boraginaceae) showed marked anti-inflammatory activity using various experimental models in rats. Artemetin significantly inhibited carrageenin-induced paw edema following oral doses from 30.4 to 153.9 mg.kg-1. The doses of 102.6 and 153.9 mg.kg-1 showed an inhibitory effect similar to that of 50.0 mg.kg-1 of calcium phenylbutazone. The ED50 value of artemetin in rats was estimated to be 67.07 mg.kg-1. Repeated administration of artemetin at doses of 67.07 mg.kg-1 for a 6-day period reduced granuloma formation with a response comparable to that of 20.0 mg.kg-1 of calcium phenylbutazone. This same dose of artemetin also reduced the vascular permeability to intracutaneous histamine. Sub-acute toxicological experiments indicated a very low toxicity.

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