Role of human papillomavirus infection and other factors in patients with head and neck squamous cell carcinoma

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Abstract
Objective: To analyse the association between high‐risk human papillomavirus (HR‐HPV) and other risk factors in the aetiology of head and neck squamous cell carcinoma (HNSCC) in an Asian population.Study Design: This study is a cross‐sectional analysis of 80 patients who were diagnosed with HNSCC. Patients' demographics, dietary habit, medical and social history were obtained. Surgical specimens from these patients were then histologically analysed using H&E stain and immunohistochemistry (IHC) for the presence of HR‐HPV primary antibody.Results: High‐risk human papillomavirus was detected in 41 patients, representing 51.3% of the 80 paraffin‐embedded tissues of HNSCC; 27.5% of these were weak positive, 10.0% medium positive and 13.8% were strongly positive for the HR‐HPV on IHC. The tongue lesions had the highest HR‐HPV infection of 72.2%. No association existed between HR‐HPV and patient's demographics, dietary habit and other predisposing factors.Conclusion: The place of HR‐HPV as a possible aetiological factor for HNSCC has further been established from this study.

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