Inhibition of angiogenesis and murine tumour growth by laminarin sulphate
Authors:
Open Access
- 1 May 1996
- journal article
- Published by Springer Nature in British Journal of Cancer
- Vol. 73 (10) , 1183-1186
Abstract
LAM S5 is a polysulphated derivative of the glucan laminarian that inhibits basic fibroblast growth factor (bFGF) binding and the bFGF-stimulated proliferation of fetal bovine heart endothelial (FBHE) cells. This report demonstrates that LAM S5 has anti-angiogenic activity, as shown by inhibition of tubule formation by endothelial cells cultured on Matrigel and inhibition of vascularisation of the chick chorioallantoic membrane. In addition, LAM S5 caused a tumour growth delay of the murine RIF-1 tumour of 2.6 days (P = 0.01).Keywords
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