Carbocyclic analogues of penicllin

Authors:
  • OMOtte Meth-Cohn
    Otte Meth-Cohn
  • ARAndrew J. Reason
    Andrew J. Reason
  • SRStanley M. Roberts
    Stanley M. Roberts
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Abstract
The synthesis of the title systems is described by cycloaddition of dimethylketen to cyclopentadiene, addition of hypobromous acid to the product and use of a nitrile-mediated rearrangement to give 4-cyano-6-exo-benzyloxy-3,3-dimethylbicylo[3.2.0]heptan-2-one(5b) and its dervatives by further modification.