Glucose transporter 1 is essential to maintain brain endothelial cell homeostasis under hyperglycemia condition

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Abstract
Glucose transporter-1 is known for regulating glucose uptake in brain endothelial cells. This study used global transcriptome analysis and diabetic mouse models to reveal the novel role of glucose transporter 1 in regulating brain endothelial cell homeostasis by reducing the inflammation response and increasing the protection mechanism. Importantly, the glucose transporter 1-dependent protection mechanism is compromised in diabetic conditions, which explains why patients with diabetes have a high risk of cerebrovascular diseases.
Funding Information
  • HHS | NIH | National Heart, Lung, and Blood Institute (HL141733)
  • NYU Langone Medical Center (Start-up fund)

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