Declining levels of serum chemokine (C‐X‐C motif) ligand 10 over time are associated with new onset of psoriatic arthritis in patients with psoriasis: a new biomarker?*

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Abstract
Background We previously found that serum levels of C‐X‐C motif chemokine 10 (CXCL10) decreased after PsA onset. Objective We measured CXCL10 levels over time in psoriasis patients who developed PsA to determine whether the drop in CXCL10 was specific to these patients and further assess its association with PsA development. Methods Prospectively followed psoriasis patients without arthritis (psoriasis cutaneous [PsC]) were assessed yearly by rheumatologists for the presence of PsA. PsC patients who developed PsA (converters) were matched to those that did not develop PsA (non‐converters) based on psoriasis duration and the interval between follow‐up visits. The duration between baseline and the first visit post‐conversion in converters was used to assign a pseudo‐conversion date in non‐converters. Linear mixed‐effects models were used to model the expression of CXCL10 over time. Results CXCL10 significantly declined over time in converters prior to PsA development with a significant difference in the trend over time between converters (n=29) and non‐converters (n=52; p<0.001). CXCL10 continued to decline after PsA onset in a subset of converters. There was a significant difference in the trend of CXCL10 levels between converters (n=24) and non‐converters (n=16; p=0.01) pre‐conversion/pseudo‐conversion. This difference remained post‐conversion (p=0.006) and was not different from the pre‐conversion period (p=0.75). Conclusion A large difference in CXCL10 was identified in PsC patients that are destined to develop PsA over time. This exploratory analysis supports the association of CXCL10 with PsA development in PsC patients and warrants further study of the predictive ability of this chemokine.
Funding Information
  • Krembil Foundation

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