Different effects of cytochalasins on the growth and differentiation of Entamoeba invadens

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Abstract
The effect of five different cytochalasins on the growth, encystation and excystation of Entamoeba invadens was examined. At 10 μM, cytochalasins B, D, E and dihydrocytochalasin B markedly inhibited growth. Encystation was inhibited by cytochalasin D at 1 μM but not by other cytochalasins at the same concentration, whereas it was inhibited by 10 μM of cytochalasins B, E and dihydrocytochalasin B as well as cytochalasin D. Excystation, which was assessed by counting the number of metacystic amoebae after inducing excystation, was markedly enhanced by cytochalasin D as previously demonstrated, whereas the enhancing effect of cytochalasins A, B and dihydrocytochalasin B was weak. In contrast, cytochalasin E at 10 μM inhibited excystation and metacystic development. These results indicate that there is a difference in the effect of different cytochalasins on the growth and differentiation of E. invadens, depending on differences in their chemical structure.

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