miR-372 promotes breast cancer cell proliferation by directly targeting LATS2

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Abstract
MicroRNAs (miRs) have previously been demonstrated to be important in the tumorigenesis and progression of breast cancer. miR‑372 was previously revealed to be involved in various types of human cancer, however its function in breast cancer remains largely unknown. The present study demonstrated that miR‑372 is frequently overexpressed in breast cancer cell lines and tissues. The downregulation of miR‑372 markedly inhibited cell proliferation, arrested the cell cycle in the G1/S phase, and increased the apoptosis of breast cancer cells. Consistently, an in vivo xenograft study also demonstrated the suppressive effects of miR‑372 knockdown on tumor growth. Further studies revealed that miR‑372 modulated the expression of large tumor suppressor kinase 2 (LATS2) by directly targeting its 3'‑untranslated region in breast cancer cells. Furthermore, silencing of LATS2 was able to rescue the effect of the miR‑372 inhibitor. Overall, the results suggest that miR‑372 functions as an oncogenic miRNA in breast cancer by targeting LATS2.

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