Synthesis of Platensimycin Analogues and Their Antibiotic Potency
Authors:
- 5 June 2008
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 341 (6) , 386-392
Abstract
Platensimycin is a natural product isolated from various strains of Streptomyces platensis which exhibits antimicrobial activity against Gram positive bacteria, including vancomycin‐ and linezolide‐resistant species. Analogues of platensimycin were synthesized from 3‐aminobenzoic acid or other aniline derivatives and several alkyl‐ and aryl‐carboxylic acids. The resulting compounds were tested in an agar diffusion assay against several bacteria and fungi.Keywords
This publication has 13 references indexed in Scilit:
- Antibacterial targets in fatty acid biosynthesisCurrent Opinion in Microbiology, 2007
- Chemistry of platensimycinTetrahedron Letters, 2007
- Adamantaplatensimycin: A Bioactive Analogue of PlatensimycinAngewandte Chemie International Edition, 2007
- Total Synthesis of PlatensimycinAngewandte Chemie International Edition, 2006
- Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity StrategyJournal of the American Chemical Society, 2006
- Platensimycin is a selective FabF inhibitor with potent antibiotic propertiesNature, 2006
- The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural ProductsSynthesis, 1981
- The Preparation of 3-Methyl-6- and -7-carboxy-2-quinoxalonesThe Journal of Organic Chemistry, 1961
- The Preparation of m-Hydroxybenzoic AcidJournal of the American Chemical Society, 1942
- NEW BENZYL ESTERS POSSESSING AN ANTI-SPASMODIC ACTION.Journal of the American Chemical Society, 1921