De la diabetes a la insuficiencia cardiaca ¿Existe la miocardiopatía diabética?
Open Access
- 12 February 2020
- journal article
- research article
- Published by Instituto Mexicano del Seguro Social in Revista Colombiana de Cardiología
- Vol. 27, 12-16
Abstract
La diabetes y la insuficiencia cardiaca son dos enfermedades altamente prevalentes. Desde 1972 existen publicaciones que demuestran cómo los pacientes con diabetes pueden desarrollar insuficiencia cardiaca, independiente de la presencia de otras causas, como la enfermedad coronaria o la hipertensión. realizar una revisión sistemática de la literatura sobre la cardiopatía diabética. se utilizaron los términos MESH diabetes e insuficiencia cardiaca y se consultó la base de datos PUBMED. Finalmente, se incluyeron los artículos publicados en inglés y español. la cardiopatía diabética es una enfermedad que ocurre como consecuencia de la hiperinsulinemia y la hiperglicemia. Los mecanismos fisiopatológicos que la originan son los cambios metabólicos en la célula miocárdica que generan oxidación, apoptosis y necrosis. Puede manifestarse como fenotipo dilatado o restrictivo. Los inhibidores del cotransportador de sodio glucosa tipo 2 (I-SGLT2) podrían tener un efecto benéfico en el tratamiento de la enfermedad. la cardiopatía diabética es una de las consecuencias de la diabetes mal controlada. Esta relación entre ambas enfermedades resalta la importancia de tratar adecuadamente la diabetes para prevenir el desarrollo de insuficiencia cardiaca. Diabetes and heart failure are two highly prevalent diseases. Since 1972, there have been publications that have demonstrated how patients with diabetes can develop heart failure, independently of the presence of other causes, like coronary disease or hypertension. To perform a systematic review of the literature on diabetic heart disease. The PubMed data base was consulted using the MESH terms, diabetes and heart failure, with articles in English and Spanish being finally included. Diabetic heart disease is an illness that occurs due to high blood insulin and glucose levels (hyperinsulinaemia and hyperglycaemia). The pathophysiological mechanisms that give rise to it are the metabolic changes in the myocardial cell that lead to oxidation, apoptosis, and necrosis. It can be express as a dilated or restrictive phenotype. The sodium-glucose cotransporter-2 (SGLT2) inhibitors could have beneficial effects in the treatment of the disease. Diabetic heart disease is one of the consequences of poorly controlled diabetes. This relationship between both diseases highlights the importance of adequately treating the diabetes in order to prevent the development of heart failure.Keywords
This publication has 30 references indexed in Scilit:
- Myocardial Steatosis Is an Independent Predictor of Diastolic Dysfunction in Type 2 Diabetes MellitusJACC, 2008
- Mitochondrial Energetics in the Heart in Obesity-Related DiabetesDiabetes, 2007
- Diabetes increases apoptosis and necrosis in both ischemic and nonischemic human myocardium: Role of caspases and poly–adenosine diphosphate–ribose polymeraseThe Journal of Thoracic and Cardiovascular Surgery, 2007
- Diabetic atherosclerosis mouse modelsAtherosclerosis, 2007
- Contributions of Inflammation and Cardiac Matrix Metalloproteinase Activity to Cardiac Failure in Diabetic CardiomyopathyDiabetes, 2007
- Advanced Glycation End ProductsCirculation, 2006
- Collagen remodelling in myocardia of patients with diabetes.Journal of Clinical Pathology, 1993
- Diabetic CardiomyopathyJAMA, 1974
- New type of cardiomyopathy associated with diabetic glomerulosclerosisThe American Journal of Cardiology, 1972
- DIABETIC ANGIOPATHYThe Lancet, 1954