Stoichiometric transport of estrone 3-sulfate among genetic variants of OATP1A2 and OATP2B1 and structural analysis by molecular dynamics simulation: Impairment of gating mechanism in the unstable inward-open conformation of OATP2B1 (Asp215Val) significantly suppress the transport activity
Authors:
- Takeshi AkiyoshiTATakeshi Akiyoshi
- Arun Kumar TonduruATArun Kumar Tonduru
- Hiroki KataokaHKHiroki Kataoka
- Tokio MoritaTMTokio Morita
- Kodai YajimaKYKodai Yajima
- Ayuko ImaokaAIAyuko Imaoka
- Kazuhiro KatayamaKKKazuhiro Katayama
- Prasanthi MedarametlaPMPrasanthi Medarametla
- Antti PosoAPAntti Poso
- Hisakazu OhtaniHOHisakazu Ohtani
- Tetsuya TerasakiTTTetsuya Terasaki
- 5 November 2025
- journal article
- Published by Elsevier in Drug Metabolism and Disposition
- Vol. 53 (12) , 100198
Abstract
No abstract availableKeywords
Funding Information
- Japan Society for the Promotion of Science (19K07173)
- Japan Society for the Promotion of Science (18K06758)
- Biokeskus Kuopio, Itä-Suomen yliopisto
- Research Council of Finland
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