Body Fat Distribution and Total Body Fat as Risk Factors for Microalbuminuria in the Obese

Authors:
  • CSClair Stevens
    Clair Stevens
  • SMSue Munro
    Sue Munro
  • JLJennifer Lingard
    Jennifer Lingard
  • MBMargaret Bermingham
    Margaret Bermingham
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Abstract
Background/Aim: Despite evidence linking type of obesity with subsequent organ malfunction, such a link with renal malfunction has not been widely researched. The aim of this study was to investigate percentage of total body fat (%TBF), and body fat distribution in relation to the renal function in overweight/obese subjects. Methods: Body mass index (BMI), waist-to-hip ratio (WHR), TBF (by bioelectric impedance), and albumin excretion rate (AER) were determined in 77 subjects: 48 overweight/obese (BMI ≧27.8 for men and ≧27.3 for women) and 29 controls (BMI Results: Obesity, irrespective of type, was significantly related to increased AER. Furthermore, in subjects who did not differ in %TBF, the age-adjusted relative risk of abnormal AER was 18 times greater in centrally obese subjects as compared with controls, while only four times greater in peripherally obese subjects. Conclusion: A significant difference in risk of renal malfunction was observed in individuals having the same %TBF, but differing in the distribution of this fat, with a central fat pattern being the greater risk.

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