Preliminary Imaging Results Using In-111 Labeled CYT-356 (Prostascintst) in the Detection of Recurrent Prostate Cancer
Authors:
- Ridgely ConantRCRidgely Conant
- Marshall ChalfantMCMarshall Chalfant
- Stefan MironSMStefan Miron
- Eric KleinEKEric Klein
- Robert BahnsonRBRobert Bahnson
- J. Patrick SpirnakJSJ. Patrick Spirnak
- Bruce CarlinBCBruce Carlin
- Errol M. BellonEBErrol M. Bellon
- Barbara RogersBRBarbara Rogers
- 1 October 1996
- journal article
- research article
- Published by Wolters Kluwer Health in Clinical Nuclear Medicine
- Vol. 21 (10) , 759-767
Abstract
To evaluate whether In-111 capromab pendetide (an antibody conjugate directed to a glycoprotein found primarily on the cell membrane of prostate tissue) radioimmunoscintigraphy can localize residual or metastatic prostatic carcinoma in 15 patients after prostatectomy and lymphadenectomy for prostatic carcinoma with rising serum prostate-specific antigen. One patient with 0.6 ng/ml serum prostate-specific antigen had normal imaging results and 14 patients had scintigraphic evidence of residual prostatic bed or metastatic prostatic carcinoma. Two patients with borderline abnormal bone scans had abnormal activity in the same regions on In-111 capromab pendetide images. All patients had negative radiographic abdominal and pelvic cross-sectional prestudy images, and there were no adverse effects related to In-111 capromab pendetide infusion and little human antimouse antibody response.Keywords
This publication has 15 references indexed in Scilit:
- Molecular Detection of Prostate Epithelial Cells from the Surgical Field and Peripheral Circulation during Radical ProstatectomyJournal of Urology, 1996
- Radioimmunoscintigraphy of Pelvic Lymph Nodes with111Indium-Labeled Monoclonal Antibody CYT-356Journal of Urology, 1994
- Patterns of lymphatic metastases at recurrence of prostate cancer: CT findingsClinical Radiology, 1994
- Lymph node staging of localized prostatic carcinoma with CT and CT-guided fine-needle aspiration biopsy: prospective study of 285 patients.Radiology, 1994
- NEOPLASMS OF THE BLADDER, PROSTATE, AND TESTISRadiologic Clinics of North America, 1994
- Defining and updating the American Cancer Society guidelines for the cancer-related checkup: prostate and endometrial cancersCA: A Cancer Journal for Clinicians, 1993
- Prostatic carcinoma: staging by clinical assessment, CT, and MR imaging.Radiology, 1987
- The Value of Computerized Tomography Scan and Magnetic Resonance Imaging in Staging Prostatic Carcinoma: Comparison with the Clinical and Histological StagingJournal of Urology, 1986
- Correlations between radiography, ultrasonography, computed tomography and pathologic findings in prostatic diseaseUrology, 1985
- The National Survey of Prostate Cancer in the United States by the American College of SurgeonsJournal of Urology, 1982