Rapid, General Access to Chiral β-Fluoroamines and β,β-Difluoroamines via Organocatalysis
- 21 January 2009
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 11 (4) , 943-946
Abstract
A rapid, general route to enantiopure β-fluoroamines and β,β-difluoroamines has been developed employing organocatalysis in both a two-pot and a one-pot procedure. Both chemical yields (64−82%) and enantioselectivity (94−98% ee) were excellent and represent a significant improvement in the art of preparing chemically diverse β-fluoroamines from readily available precursors.Keywords
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