Antimicrobial Activity of a Novel Freshwater Planctomycete Lacipirellula parvula PX69T

Authors:
Publisher website
Google Scholar
Abstract
Planctomycetes are a phylogenetic group of bacteria with complex cell organization, large genomes and a wide spectrum of genome-encoded secondary metabolites. As suggested by analysis of available planctomycete genomes, these bacteria represent a promising source of potentially novel biologically active compounds. The number of cultured planctomycetes, however, remains limited. This study was undertaken in order to assess the presence of antimicrobial activity and its spectrum in the recently described freshwater planctomycete Lacipirellula parvula PX69T representing the novel family Lacipirellulaceae. The genome of strain PX69T contained 6 gene clusters encoding type III polyketide synthases, non-ribosomal peptide synthetases, and other secondary metabolites, which displayed low similarity to those in other bacteria. Strain PX69T was shown to exhibit antimicrobial activity against a number of test microorganisms. The highest antimicrobial activity, up to 83‒87% of growth inhibition, was observed against Staphylococcus aureus and Candida albicans. The medium composition and the cultivation time have been optimized in order to maximize antimicrobial activity of strain PX69T.

This publication has 23 references indexed in Scilit: