Two Enzymes Which Phosphorylate Neomycin and Kanamycin in Escherichia coli Strains Carrying R Factors
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Open Access
- 1 February 1973
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 3 (2) , 266-269
Abstract
Two enzymes which phosphorylate neomycin and kanamycin have been detected in Escherichia coli strains carrying R factors. Neomycin-kanamycin phosphotransferase I can phosphorylate neomycin and kanamycin, but not butirosin. Neomycin-kanamycin phosphotransferase II can phosphorylate all three antibiotics. The enzymes also differ in their response to certain inhibitors of phosphorylation. Neomycin-kanamycin phosphotransferase II is found in certain strains of Pseudomonas aeruginosa .Keywords
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