Selectivity of electrospray response in small polymer analysis by mass spectrometry
- 2 October 2006
- journal article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 20 (21) , 3188-3192
Abstract
The selectivity of electrospray was explored for a small poly(ethylene)glycol by comparing the oligomer response obtained from direct polymer introduction in flow injection analysis with the signal recorded in high‐performance liquid chromatography/mass spectrometry (HPLC/MS). When the oligomer mixture was ionized, a suppression effect was measured for all but the more hydrophobic congeners for which the response was enhanced. This result would reflect the influence of electrospray droplet chemical composition on the equilibrium partitioning coefficient in Enke's model. On average, the electrospray selectivity observed for the studied poly(ethylene)glycol did not affect the molecular weight distribution parameters as response for the most concentrated oligomers was suppressed to the same extent while over‐expressed largest congeners had a low contribution to the total polymer sample. Copyright © 2006 John Wiley & Sons, Ltd.Keywords
This publication has 33 references indexed in Scilit:
- Factors influencing the determination of analyte ion surface partitioning coefficients in electrosprayed dropletsJournal of the American Society for Mass Spectrometry, 2001
- Effects of salt concentration on analyte response using electrospray ionization mass spectrometryJournal of the American Society for Mass Spectrometry, 1999
- Dependence of ion intensity in electrospray mass spectrometry on the concentration of the analytes in the electrosprayed solutionAnalytical Chemistry, 1993
- Electrospray mass spectrometry: a study on some aqueous solutions of metal saltsJournal of the American Society for Mass Spectrometry, 1992
- Effect of the conductivity of the electrosprayed solution on the electrospray current. Factors determining analyte sensitivity in electrospray mass spectrometryAnalytical Chemistry, 1991
- Gradient HPLC of Copolymers and Chromatographic Cross-Fractionation1991
- Factors determining relative sensitivity of analytes in positive mode atmospheric pressure ionization mass spectrometryAnalytical Chemistry, 1988
- Atmospheric pressure ion evaporation-mass spectrometryInternational Journal of Mass Spectrometry and Ion Physics, 1983
- Field induced ion evaporation from liquid surfaces at atmospheric pressureThe Journal of Chemical Physics, 1979
- On the evaporation of small ions from charged dropletsThe Journal of Chemical Physics, 1976