Effect of Comp on Colorectal Cancer Cell Migration

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Abstract
A publicly accessible online database was utilized in this study to investigate COMP, which is aberrantly expressed in a range of malignancies. It was discovered that colorectal cancer had significant levels of COMP expression. This finding was corroborated by Western Blot and RT-qPCR analysis tests on colorectal cancer cell lines. In order to study the effect of COMP on colorectal cancer migration, we investigated the expression of mRNA and protein levels in colorectal cancer cell lines knocked down by COMP, and the effect of COMP on the migration of SW480 cell line was studied using Transwell, wound healing assay. The findings demonstrated that the migration of colorectal cancer cell lines was suppressed by COMP expression knockdown. These findings offer a theoretical foundation for the use of COMP as a novel clinical treatment target and possible marker for the identification of colorectal cancer metastases.
Funding Information
  • Natural Science Foundation of Hubei Province (2022EHB035)

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