Asymmetric Hydroxylative Phenol Dearomatization through In Situ Generation of Iodanes from Chiral Iodoarenes and m‐CPBA
Authors:
- Stéphane QuideauSQStéphane Quideau
- Alain ChénedéACAlain Chénedé
- 3 June 2009
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 48 (25) , 4605-4609
Abstract
′I′ is all the hype: A twofold excess of iodoarene in the title reaction leads to ortho‐quinols in good yields, whereas organocatalytic versions of this reaction enable subsequent epoxidation in a regio‐ and diastereoselective fashion. Chiral iodobiarenes led to enantioselectivities up to 50 % ee. m‐CPBA=meta‐chloroperoxybenzoic acid. magnified imageKeywords
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