Physicochemical and antimicrobial properties of in situ crosslinked alginate/hydroxypropyl methylcellulose/ε‐polylysine films

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Abstract
In the present study, in situ crosslinked films were easily prepared by the spray deposition of Phase A, composed by sodium alginate (Alg), hydroxypropyl methylcellulose (HPMC), ε‐polylysine (ε‐PL), and plasticizers, followed by the spray deposition of Phase B (Ca2+ ions) on polystyrene dishes. The effect of the amount of plasticizer, HPMC, and ε‐PL in Phase A on the films properties was explored in a set of 12 systems. Fourier transform infrared vibrational spectroscopy in the attenuated total reflectance mode revealed that plasticizers compete with Ca2+ ions for complexation with Alg. Films with high HPMC content and low content of plasticizer and ε‐PL presented the best mechanical properties. The best system presented Young modulus of 0.76 ± 0.10 GPa, water vapor transmission of 5.35 ± 0.28 mg cm−2 h−1, swelling ratio of 1374 ± 97%, 99.99% reduction against Gram‐negative Escherichia coli bacteria, and 99.9% reduction against Gram‐positive Staphylococcus aureus bacteria. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48832.
Funding Information
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (306848/2017, 421014/2018‐0)

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