When Molecules Meet in Water‐Recent Contributions of Supramolecular Chemistry to the Understanding of Molecular Recognition Processes in Water
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Open Access
- 3 April 2022
- journal article
- review article
- Published by Wiley in ChemistryOpen
- Vol. 11 (4) , e202200028
Abstract
Molecular recognition processes in water differ from those in organic solvents in that they are mediated to a much greater extent by solvent effects. The hydrophobic effect, for example, causes molecules that only weakly interact in organic solvents to stay together in water. Such water‐mediated interactions can be very efficient as demonstrated by many of the synthetic receptors discussed in this review, some of which have substrate affinities matching or even surpassing those of natural binders. However, in spite of considerable success in designing such receptors, not all factors determining their binding properties in water are fully understood. Existing concepts still provide plausible explanations why the reorganization of water molecules often causes receptor‐substrate interactions in water to be strongly exothermic rather than entropically favored as predicted by the classical view of the hydrophobic effect.Keywords
This publication has 254 references indexed in Scilit:
- Pillar[6]arene/Paraquat Molecular Recognition in Water: High Binding Strength, pH-Responsiveness, and Application in Controllable Self-Assembly, Controlled Release, and Treatment of Paraquat PoisoningJournal of the American Chemical Society, 2012
- Multivalency as a Chemical Organization and Action PrincipleAngewandte Chemie International Edition, 2012
- Multivalenz als chemisches Organisations‐ und WirkprinzipAngewandte Chemie, 2012
- Measurement of radon and xenon binding to a cryptophane molecular hostProceedings of the National Academy of Sciences, 2011
- Anion Binding to Hydrophobic Concavity Is Central to the Salting-in Effects of Hofmeister ChaotropesJournal of the American Chemical Society, 2011
- New Ultrahigh Affinity Host−Guest Complexes of Cucurbit[7]uril with Bicyclo[2.2.2]octane and Adamantane Guests: Thermodynamic Analysis and Evaluation of M2 Affinity CalculationsJournal of the American Chemical Society, 2011
- The inverse and direct Hofmeister series for lysozymeProceedings of the National Academy of Sciences, 2009
- A Synthetic Lectin for O‐Linked β‐N‐AcetylglucosamineAngewandte Chemie International Edition, 2009
- A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy–entropy compensationProceedings of the National Academy of Sciences, 2007
- Interfaces and the driving force of hydrophobic assemblyNature, 2005