Pyrrole chemistry. XXVI. A synthesis of porphobilinogen from pyrrole

Authors:
  • BDBasil J. Demopoulos
    Basil J. Demopoulos
  • HAHugh J. Anderson
    Hugh J. Anderson
  • CLCharles E. Loader
    Charles E. Loader
  • KFKurt Faber
    Kurt Faber
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Abstract
A synthetic strategy has been developed which enables pyrrole to be used as the starting material for the synthesis of 2,3,4-trisubstituted pyrroles of the type used to construct porphyrins. The total synthesis of porphobilinogen has been accomplished as a demonstration of the applicability of the approach.