Nelfinavir, Efavirenz, or Both after the Failure of Nucleoside Treatment of HIV Infection

Authors:
  • RBRonald J. Bosch
    Ronald J. Bosch
  • SHScott M. Hammer
    Scott M. Hammer
  • SLSong-Heng Liou
    Song-Heng Liou
  • HKHarold Kessler
    Harold Kessler
  • MPMichael F. Para
    Michael F. Para
  • JEJoseph Eron
    Joseph Eron
  • HVHernan Valdez
    Hernan Valdez
  • MDMarjorie Dehlinger
    Marjorie Dehlinger

Abstract
The optimal antiretroviral treatment for patients who have human immunodeficiency virus (HIV) viremia despite treatment with nucleoside reverse-transcriptase inhibitors (nucleoside analogues) remains uncertain. We studied treatment with regimens that combined two nucleoside analogues, at least one of which was new, with the protease inhibitor nelfinavir, the nonnucleoside reverse-transcriptase inhibitor efavirenz, or both.

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