Species differences in the generation of the chiral sulfoxide metabolite of albendazole in sheep and rats
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Abstract
The prochiral anthelmintic drug albendazole was administered orally to sheep and rats. Blood samples were taken at standardized intervals during the time course of the plasma kinetics: 18 h in rats and 48 h in sheep. The enantiomeric ratio of the sulfoxide metabolite was determined by means of HPLC on a chiral stationary phase, the chiral selector of which was a N‐3,5‐dinitrobenzoyl derivative of (S)‐tyrosine. Two enantiomers were detected in both animal species but their ratios were inverted in rat vs. sheep. The evolution of the ratio is turned from a racemate at 15 min to 60(−):40(+) at 12 h in rats, while it moved from 23(−):77(+) at 3 h to 4(−):96(+) at 36 h after administration in sheep.Keywords
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