Catheter-directed Gastric Artery Chemical Embolization for Modulation of Systemic Ghrelin Levels in a Porcine Model: Initial Experience

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Abstract
Purpose: To prospectively test, in a porcine model, the hypothesis that use of catheter-directed gastric artery chemical embolization (GACE) can result in substantial suppression of systemic ghrelin levels. Materials and Methods: The institutional animal care and use committee approved this study. Adult healthy swine (40–45 kg, n = 8) were tested. GACE was performed by infusing morrhuate sodium selectively into the left gastric artery. Six swine (animals A–F) underwent left GACE by using a dose-escalating regimen of morrhuate sodium, whereas two control swine underwent a sham procedure. Weight and fasting plasma ghrelin levels were compared in swine at baseline and at weeks 1–4. At week 4, stomachs were excised and analyzed. Analysis of the change in ghrelin values and weight was performed with both paired t test and unpaired Student t test. Results: In control swine (n = 2), there was no significant difference in ghrelin values before (844.8 pg/mL ± 40 [standard deviation]) and after (997 pg/mL ± 93) the...

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