Triple‐Helical Recognition of RNA Using 2‐Aminopyridine‐Modified PNA at Physiologically Relevant Conditions
Authors:
- 4 November 2012
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 51 (50) , 12593-12596
Abstract
Peptide nucleic acids containing thymidine and 2‐aminopyridine (M) nucleobases form stable and sequence‐selective triple helices with double‐stranded RNA at physiologically relevant conditions. The M‐modified PNA showed unique RNA selectivity by having two orders of magnitude higher affinity for the double‐stranded RNAs than for the same DNA sequences.Keywords
This publication has 30 references indexed in Scilit:
- Recent Advances in Developing Small Molecules Targeting RNAACS Chemical Biology, 2012
- Recognition of Double-Stranded RNA by Guanidine-Modified Peptide Nucleic AcidsBiochemistry, 2011
- Triple helical recognition of pyrimidine inversions in polypurine tracts of RNA by nucleobase-modified PNAChemical Communications, 2011
- Short Peptide Nucleic Acids Bind Strongly to Homopurine Tract of Double Helical RNA at pH 5.5Journal of the American Chemical Society, 2010
- The Centrality of RNACell, 2009
- Targeting RNA with Small MoleculesChemical Reviews, 2008
- Stable and Selective Recognition of Three Base Pairs in the Parallel Triple‐Helical DNA Binding MotifAngewandte Chemie International Edition, 2004
- Stable and Selective Recognition of Three Base Pairs in the Parallel Triple-Helical DNA Binding MotifAngewandte Chemie, 2004
- A Novel Peptide Nucleic Acid Monomer for Recognition of Thymine in Triple-Helix StructuresJournal of the American Chemical Society, 1997
- Comparison of the acidities and basicities of amino-substituted nitrogen heterocyclesThe Journal of Organic Chemistry, 1978