Comparative Study of Three Different Fecal Calprotectin Immunoassays: TriCAL Study

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  • 1 November 2020
    • journal article
    • research article
Abstract
Objective. Calprotectin is a biomarker of gastrointestinal inflammation and disease activity. We aimed to evaluate the performance of a new fecal calprotectin (FC) test (CALiaGold (R)) in comparison with two other rapid FC immunoassays. Methods. Fecal samples were analyzed with all three FC tests. Correlation between the FC tests was assessed. Agreement to discriminate FC-positive samples was also evaluated according to the manufacturers' cut-off values. Results. A correlation coefficient of over 0.800 was found in all comparisons. Lower deviation of linearity was observed between immunoturbidimetric assays. Agreement on FC-positive sample detection was reduced in comparisons with the immunochromatographic assay. Conclusions. The CALiaGold (R) test showed good performance for FC assessment. Better correlation and agreement between immunoturbidimetric assays were confirmed.