Looking Forward in Pharmaceutical Process Chemistry
- 7 August 2009
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 325 (5941) , 701-704
Abstract
Core activities of process chemistry involve the synthesis of drug candidates at a scale that supports clinical evaluations and the creation of a manufacturing process that is safe, robust, and cost effective. Innovative problem solving has always been a key element in process chemistry and will be increasingly important for addressing emerging challenges in science, globalization, and commoditization. The acquisition and creation of platform chemical technologies that enable rapid problem solving through the use of high-throughput experimentation will continue to be an important focus going forward. Linking and deploying platforms throughout the discovery-development continuum is expected to enable drug discovery. Increasing collaboration with academia will also become more important for accessing technical solutions and providing the next generation of innovative problem solvers.Keywords
This publication has 8 references indexed in Scilit:
- Chemical Process Research and Development in the 21st Century: Challenges, Strategies, and Solutions from a Pharmaceutical Industry PerspectiveAccounts of Chemical Research, 2009
- The advent and development of organocatalysisNature, 2008
- Microscale HPLC Predicts Preparative Performance at Millionfold ScaleOrganic Process Research & Development, 2008
- Enzyme optimization: moving from blind evolution to statistical exploration of sequence–function spaceTrends in Biotechnology, 2008
- Catalytic C–H functionalization by metal carbenoid and nitrenoid insertionNature, 2008
- Adsorbent Screening Using Microplate Spectroscopy for Selective Removal of Colored Impurities from Active Pharmaceutical IntermediatesOrganic Process Research & Development, 2008
- Unlocking the Potential of Asymmetric Hydrogenation at MerckAccounts of Chemical Research, 2007
- Ibuprofen1999