Enhanced Fluorescence-Based Optical Sensor Performance Using a Simple Optical Collection Strategy
- 20 December 2011
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Photonics Technology Letters
- Vol. 24 (6) , 425-427
Abstract
In this letter, we report a simple optical strategy designed to significantly enhance the fluorescence collection efficiency of planar substrate-based optical sensors. The strategy involves the use of refractive and reflective optical elements that permit supercritical angle fluorescence to be transmitted through the lower surface of the planar substrate and redirected toward an optical detector. Importantly, this approach facilitates simple integration with existing multianalyte sensor systems and microfluidic platforms by leaving the sensor's upper planar surface unstructured. In comparison to a conventional planar substrate configuration, the proposed approach can provide better than an order of magnitude (factor of 20) enhancement in the fluorescence intensity detected. It is envisaged that this approach will have significant potential in a range of application areas where there is need for low-cost optical sensor technologies.Keywords
This publication has 13 references indexed in Scilit:
- Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS)Lab on a Chip, 2010
- Surface plasmon-coupled emission (SPCE)-based immunoassay using a novel paraboloid array biochipBiosensors and Bioelectronics, 2009
- Fabrication of holographic diffractive optical elements for enhancing light collection from fluorescence-based biochipsOptics Letters, 2008
- Novel hybrid optical sensor materials for in-breath O2analysisThe Analyst, 2007
- Rapid detection of foodborne contaminants using an Array BiosensorSensors and Actuators B: Chemical, 2006
- Platform for enhanced detection efficiency in luminescence-based sensorsElectronics Letters, 2005
- A portable automated multianalyte biosensorTalanta, 2005
- Supercritical angle fluorescence (SAF) microscopyOptics Express, 2004
- Theory of the radiation of dipoles placed within a multilayer systemApplied Optics, 2000
- Fluorescence emission at dielectric and metal-film interfacesJournal of the Optical Society of America B, 1987