The impact of maternal metabolic flexibility during gestation on infant adiposity in individuals with obesity

Authors:
Open Access
Publisher website
Google Scholar
Abstract
This study revealed that maternal metabolic flexibility—the ability to switch between fuel sources depending on availability—and greater reliance on lipid oxidation during fasting in late pregnancy were linked to higher infant birth weight and adiposity, independent of gestational weight gain. These findings suggest that maternal substrate oxidation influences fetal nutrient supply and, consequently, growth, thereby playing a key role in shaping neonatal body composition and long-term health outcomes.
Funding Information
  • National Institutes of Health (1R01DK09917)
  • National Institutes of Health (P30DK072476)
  • American Heart Association (25POST1365227)

This publication has 16 references indexed in Scilit: