MDAtlas: A Multiomics Meniere Disease Database of Genes and Cells
Authors:
- Kiana Bagheri-LotfabadKBKiana Bagheri-Lotfabad
- Pablo Cruz-GranadosPablo Cruz-Granados
- Muhammad UmairMUMuhammad Umair
- Alberto M. Parra-PerezAPAlberto M. Parra-Perez
- Sayedali MohseniSMSayedali Mohseni
- Mai T. PhamMPMai T. Pham
- Giselle Bianco-BortolettoGBGiselle Bianco-Bortoletto
- Sung Huhn KimSKSung Huhn Kim
- Rick A. FriedmanRFRick A. Friedman
- Daniel BurnDBDaniel Burn
- Jose A. Lopez-EscamezJose A. Lopez-Escamez
- the Meniere Disease Multiomic Aggregation Consortium (MD-MAC)T(the Meniere Disease Multiomic Aggregation Consortium (MD-MAC)
Preprint
Abstract
The MDAtlas is a crowdsourcing initiative to provide an open access resource with multiomic dataset about Meniere Disease (MD) -a debilitating audiovestibular disorder- to the scientific/medical community. The platform ( https://multiomic-md.sydney.edu.au ) integrates anonymised genomic, transcriptomic and epigenomic datasets from several MD cohorts with diverse ancestry through the MD multiomic Agreggation Consortium (MD-MAC), helping users investigate common and rare genomic variability, immune cell gene expression, and DNA methylation patterns involved in these conditions. MDAtlas supports secure data upload, advanced filtering, and easy downloading, allowing researchers to compare datasets across populations and discover new disease mechanisms or biomarkers for diagnosis and therapy. By providing interactive tools and harmonized data, MDAtlas accelerates scientific progress and collaboration in hearing and vestibular research.Keywords
This publication has 23 references indexed in Scilit:
- An ultra-rare missense variant in the KIF1B gene linked to autoinflammatory Menière’s diseasenpj Genomic Medicine, 2025
- Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere Disease: A longitudinal studyClinical Immunology, 2024
- An overload of missense variants in the OTOG gene may drive a higher prevalence of familial Meniere disease in the European populationHuman Genetics, 2024
- Cytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere DiseaseGenes & Immunity, 2024
- Single-cell immune profiling of Meniere Disease patientsClinical Immunology, 2023
- Types of Inheritance and Genes Associated with Familial Meniere DiseaseJournal of the Association for Research in Otolaryngology, 2023
- Defective α‐tectorin may involve tectorial membrane in familial Meniere diseaseClinical and Translational Medicine, 2022
- DVPred: a disease-specific prediction tool for variant pathogenicity classification for hearing lossHuman Genetics, 2022
- Variant interpretation using population databases: Lessons from gnomADHuman Mutation, 2021
- Genomic Landscape and Mutational Signatures of Deafness-Associated GenesThe American Journal of Human Genetics, 2018