CANINE ORAL NONTONSILLAR SQUAMOUS CELL CARCINOMA

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Abstract
The records of 33 dogs treated with radiation therapy for nontonsillar oral squamous cell carcinoma (SCC) were reviewed to determine which, if any, prognostic factors affected local tumor recurrence and survival. Information was collected on nine factors: age, sex, anatomic subsite, intraoral location, bone involvement, radiation dose, portal size, and tumor recurrence. Product limit survival estimates indicated than only anatomic subsite was significantly related to disease‐free interval. Mean disease‐free interval was 12.0, 3.4, and 1.8 months for maxilla, mandible, and soft tissue subsites, respectively. Four factors were significantly associated with survival. The intraoral location (listed in descending survival time: rostral > caudal > rostral and caudal), tumor recurrence (no > yes), relative portal size (less than 100 cm2/m2 > greater than or equal to 100 cm2/m2), and age at diagnosis (less than or equal to 6 years > greater than 6 years) were of prognostic importance. Based on these data, a prospective randomized clinical trial for the treatment of nontonsillar oral SCC would be appropriate.

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