A Rational Approach Towards a New Ferrocenyl Pyrrolidine for Stereoselective Enamine Catalysis
- 6 May 2013
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 19 (24) , 7696-7700
Abstract
Ironing out the details: Proline and pyrrolidine derivatives (Hayashi- Jørgensen catalysts) are considered "work horses" in organocatalysis. This report describes a new effective ferrocenyl pyrrolidine catalyst that is able to perform well in benchmark organocatalytic reactions (see figure). The ferrocene moiety controls the conformational space and a simple alkyl group effectively covers a face of the derived enamine. This new framework can find applications in organocatalysis, and in general, in new ligand design.Keywords
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