Brain Regional α-[11C]Methyl-L-Tryptophan Trapping in Medication-Free Patients With Obsessive-Compulsive Disorder
Authors:
- Alexandre BerneyABAlexandre Berney
- Marco LeytonMLMarco Leyton
- Paul GravelPGPaul Gravel
- Igor SibonISIgor Sibon
- Debbie SookmanDSDebbie Sookman
- Pedro Rosa NetoPNPedro Rosa Neto
- Mirko DiksicMDMirko Diksic
- Akio NakaiANAkio Nakai
- Gilbert PinardGPGilbert Pinard
- Christo TodorovCTChristo Todorov
- Hidehiko OkazawaHidehiko Okazawa
- Pierre BlierPBPierre Blier
Open Access
- 1 July 2011
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 68 (7) , 732-741
Abstract
Obsessive-compulsive disorder (OCD) is a complex and often disabling disorder characterized by intrusive anxiogenic thoughts (obsessions) and repetitive stereotyped behaviors (compulsions).1 Functional neuroimaging, neurosurgical lesion, and deep brain stimulation studies have implicated a limbic corticostriatal circuit that includes the orbitofrontal cortex, anterior cingulate, and caudate nucleus.2-5Keywords
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