Heparin Cofactor Activity and Antithrombin III Concentration in Plasma Related to Age and Sex

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Abstract
Heparin cofactor activity and antithrombin III (At‐III) concentration were measured in plasma from 219 healthy men and 177 women. Narrow ranges for heparin cofactor activity and At‐III concentration were found. The standard deviation for heparin cofactor activity in men and women was 8.6 and 10.1, respectively, for At‐III concentration 10.4 and 12.5In men, mean heparin cofactor activity and mean At‐III concentration decreased significantly with increasing age.In women, mean heparin cofactor activity and mean At‐III concentration tended to be lower in fertile age.Hereditary At‐III deficiency was detected in one individual.