Photoredox-Catalyzed C–H Functionalization Reactions
Top Cited Papers
- 29 September 2021
- journal article
- review article
- Published by American Chemical Society (ACS) in Chemical Reviews
- Vol. 122 (2) , 1925-2016
Abstract
The fields of C–H functionalization and photoredox catalysis have garnered enormous interest and utility in the past several decades. Many different scientific disciplines have relied on C–H functionalization and photoredox strategies including natural product synthesis, drug discovery, radiolabeling, bioconjugation, materials, and fine chemical synthesis. In this Review, we highlight the use of photoredox catalysis in C–H functionalization reactions. We separate the review into inorganic/organometallic photoredox catalysts and organic-based photoredox catalytic systems. Further subdivision by reaction class—either sp2 or sp3 C–H functionalization—lends perspective and tactical strategies for use of these methods in synthetic applications.Keywords
Funding Information
- National Institute of General Medical Sciences (1R35GM136330-01)
This publication has 529 references indexed in Scilit:
- Catalytic Asymmetric α-Acylation of Tertiary Amines Mediated by a Dual Catalysis Mode: N-Heterocyclic Carbene and Photoredox CatalysisJournal of the American Chemical Society, 2012
- Visible‐Light Photoredox Catalysis in FlowAngewandte Chemie International Edition, 2012
- Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization ReactionsAccounts of Chemical Research, 2011
- Room-Temperature C–H Arylation: Merger of Pd-Catalyzed C–H Functionalization and Visible-Light PhotocatalysisJournal of the American Chemical Society, 2011
- Photoredox Catalysis: A Mild, Operationally Simple Approach to the Synthesis of α‐Trifluoromethyl Carbonyl CompoundsAngewandte Chemie International Edition, 2011
- Enantioselective α-Benzylation of Aldehydes via Photoredox OrganocatalysisJournal of the American Chemical Society, 2010
- Direct C−H Arylation of Electron-Deficient Heterocycles with Arylboronic AcidsJournal of the American Chemical Society, 2010
- Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox OrganocatalysisJournal of the American Chemical Society, 2009
- Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond ActivationChemical Reviews, 2009
- Organocatalysis in Radical Chemistry. Enantioselective α-Oxyamination of AldehydesJournal of the American Chemical Society, 2007