Ionic Liquids as Organocatalysts for Nucleophilic Fluorination: Concepts and Perspectives

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Abstract
Besides their extremely useful properties as solvent, ionic liquids (ILs) are now considered to be highly instructive tools for enhancing the rates of chemical reactions. The ionic nature of the IL anion and cation seems to be the origin of this fascinating function of ILs as organocatalyst/promoter through their strong Coulombic forces on other ionic species in the reaction and also through the formation of hydrogen bonds with various functional groups in substrates. It is now possible to tailor-make ILs for specific purposes as solvent/promoters in a variety of situations by carefully monitoring these interactions. Despite the enormous potentiality, it seems that the application of ILs as organocatalysts/promoters for chemical reactions have not been fully achieved so far. Herein, we review recent developments of ILs for promoting the nucleophilic reactions, focusing on fluorination. Various aspects of the processes, such as organocatalytic capability, reaction mechanisms and salt effects, are discussed.
Funding Information
  • Korea Research Foundation (NRF-2019R1F1A1057609, 2020R1A2C1009017, 10080450)
  • Ministry of Science and ICT (MSIT) (NRF-2019R1F1A1057609, 2020R1A2C1009017, 10080450)
  • MOTIE (Ministry of Trade, Industry & Energy) (NRF-2019R1F1A1057609, 2020R1A2C1009017, 10080450)
  • Korea Semiconductor Research Consortium (NRF-2019R1F1A1057609, 2020R1A2C1009017, 10080450)

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