Chinese Hamster Ovary Cell Line Instability: Causes, Mitigation, and Prediction

This publication has 81 references indexed in Scilit:

• Early prediction of instability of chinese hamster ovary cell lines expressing recombinant antibodies and antibody‐fusion proteins
  Biotechnology and Bioengineering, 2011
• Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells
  Biotechnology and Bioengineering, 2011
• First CHO genome
  Nature Biotechnology, 2011
• The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line
  Nature Biotechnology, 2011
• Effect of different UCOE-promoter combinations in creation of engineered cell lines for the production of Factor VIII
  BMC Research Notes, 2011
• Promoter methylation and transgene copy numbers predict unstable protein production in recombinant chinese hamster ovary cell lines
  Biotechnology and Bioengineering, 2011
• Non-coding RNAs as regulators of gene expression and epigenetics
  Cardiovascular Research, 2011
• Maximizing productivity of CHO cell‐based fed‐batch culture using chemically defined media conditions and typical manufacturing equipment
  Biotechnology Progress, 2010
• Virus susceptibility of Chinese hamster ovary (CHO) cells and detection of viral contaminations by adventitious agent testing
  Biotechnology and Bioengineering, 2010
• Regulation of Recombinant Monoclonal Antibody Production in Chinese Hamster Ovary Cells: A Comparative Study of Gene Copy Number, mRNA Level, and Protein Expression
  Biotechnology Progress, 2006